Living with Chronic Pain and Illness? You May Be Suffering from a Toxicity Disorder

Anyone can be at risk of being exposed to and affected by environmental toxins. Exposure can occur in your own home, at work, or while traveling. The good news is that for most people the liver is able to break down these toxins so they can pass through the intestines and be excreted from the body. However, approximately 20 percent of the general population lacks the enzymes needed to break down toxins for elimination, leaving this group particularly vulnerable. Instead of being excreted, harmful toxins can be reabsorbed through the lining of the intestines back into the body. The body then sequesters them wherever it can, damaging the muscle tissue, nerves, and nervous tissues in those “holding areas.”

You can be exposed to toxins in the following ways:

  • By ingesting contaminated food, beverages, and water.
  • By inhaling aerosolized particles in the air.
  • Through direct contact with mucus from eyes, nose, mouth, etc…
  • Through direct contact with the skin

If you think you have been exposed to toxins that are affecting your health, call and speak with a nurse today: 703-532-4892, ext. 2.

Not all toxins are the same

Biotoxins are toxic substances from biological sources, like plants, bacteria, molds, and animals that alter the body’s normal biological systems that manage digestion, respiration, circulation, joint flexibility, etc. When this happens the resulting condition is called biotoxicity.

Neurotoxins affect the nervous system and disrupt the normal functioning of neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. This is called neurotoxicity.

Neurotoxins can be of natural or manmade origin. For example, neurotoxins can be found in molds, heavy metals (lead, mercury), and insect bites, as well as in pesticides, food preservatives (aspartame), and substances used in chemotherapy, radiation treatments, and drug therapy, among other things.

Mycotoxins are a type of biotoxin and the byproducts of fungi (molds) that can have toxic effects on humans and animals. Aspergillus, Penicillium, Stachybotrys, and Fusarium are some of the more common fungi that produce the following toxic offspring: Aflatoxins, Gliotoxins, Ochratoxins, and Trichothecenes.

Mycotoxins are primarily found in:

  1. Structures: In water-damaged homes and buildings
  2. Food: Common contaminants of human food products, like wine, coffee beans, nuts, cereal grains (wheat, corn, barley, etc…) and animal feed. They can also enter the food chain through food products, such as milk, meat, and eggs, obtained from animals that are fed mycotoxin-contaminated feed.

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Health effects of mold toxicity

Mycotoxins and leaky gut: The job of the small intestine is to allow nutrients to pass through its lining so they can be absorbed into the bloodstream and circulated to all the major organs. But it also works as a filter to prevent foreign or toxic substances from entering the bloodstream. When there is damage to the lining and foreign substances are able to penetrate this is called leaky gut or intestinal permeability. Since we now know that 70-80% of our immune system is located in our gut it is not surprising that the effects of leaky gut can be serious.

Researchers investigated the presence of mycotoxins in the gastrointestinal tract and concluded that Candida Albicans, one of the pathogenic fungi residing in the intestines, harmless in small amounts, starts producing gliotoxins if its number outgrows the other beneficial bacterial species in the gut, causing a myriad of neurological and gastrointestinal symptoms. Exposure to Candida Albicans and other mycotoxins results in:

  • Disrupting intestinal integrity causing dysbiosis (imbalance in gut bacteria) or leaky gut
  • Disrupting the microbiome
  • Suppressing the local immune response in the intestines

Neurocognitive Symptoms: In the brain, the glial cells (microglia and astrocytes) are part of an interactive network of cells that work to protect the nerves and brain from damage and ensure their proper development. Research shows that exposure to mycotoxins can suppress and impair their proper functioning, putting an individual’s cognitive development and/or function at risk.

A research study that measured IQ scores in 277 six-year-old children, who were exposed to indoor mold for more than 2 years, showed IQ deficits of approximately 10 points using a scale of intelligence, exemplifying the dangers of exposure on cognitive development in early childhood.

Other classic neurologic disorders that result from mycotoxin exposure include pain syndromes and depression, movement disorders, delirium, dementia, and balance and coordination disorders.

Mold toxicity is one of the major toxicity conditions we see at the Kaplan Center. Over the years we have gained a better understanding of the pathophysiology, or disease process, of environmental toxicity and have developed a successful treatment protocol. We have been delighted to see an extraordinary resolution of symptoms in about 50 percent of patients, and notable improvement in another 40 percent. Obviously, the protocol is not a cure-all, but it has helped a number of patients feel significantly better.

What Are Common Symptoms of Biotoxicity & Neurotoxicity?

The following is a list of symptoms that may indicate the presence of biotoxins or neurotoxins in your body:

Joint PainMuscle PainChronic Headaches
Fatigue – Digestive Problems – Decreased Ability to Focus
Sleep ProblemsDecreased LibidoWeight gain / Obesity
DepressionAnxiety – Mood Swings
– Poor Memory – Irritability – Wheezing

Are the Symptoms of Biotoxicity & Neurotoxicity Similar to Those of Other Disease Conditions?

Yes. Because the symptoms of biotoxicity and neurotoxicity are similar to those of other diseases toxicity is often overlooked as the underlying cause of illness.

Can I Be Tested for Biotoxicity or Neurotoxicity?

If you are experiencing any of the symptoms listed above, and, especially if your condition has not responded to conventional medical treatment, the Kaplan Center recommends the following steps:

  1. (And most important!) Take the time to talk with your doctor about your history of exposure to environmental toxins.
  2. Take an On-line Visual Contrast Sensitivity Test (VCS). This non-invasive test is a sensitive indicator of your exposure to a variety of toxins. There are a number of online resources that offer this test for a small fee.
  3. Undergo genetic testing (HLA-testing) to determine if your body has the enzymes necessary to breakdown biotoxins.
  1. Undergo advanced testing. There are a variety of tests that can detect the presence of toxins (including mycotoxins, heavy metals, infectious sources, food additives, pesticides, and other toxic chemicals). Talk to your physician about which test(s) may be most appropriate for you, based on your history of exposure
  2. Test for leaky gut. When the protective filtering system within the intestines is compromised, it is known as Intestinal Permeability – or leaky gut. Toxins and other substances that would normally have been kept within the gastrointestinal (GI) tract and eliminated are now able to get into the bloodstream and circulate throughout the body.

Is There an Effective Treatment for Biotoxicity and Neurotoxicity?

There are a variety of treatments available to patients suffering from biotoxicity or neurotoxicity disorder, but there is certainly no “one-size-fits-all” remedy. If the underlying cause of your pain or illness is biotoxicity or neurotoxicity, your treatment plan must include a detoxification regime or your overall recovery is likely to be incomplete and slower than it needs to be. Your treatment plan should be individually tailored after consideration of your overall medical history; your current symptoms; your genetic makeup; your history of exposure to biotoxins and your lifestyle. In essence, a detoxification regime is designed to “draw out” the biotoxins from whichever tissue they have been stored and “bind” the toxins at the molecular level so they can finally be eliminated from the body.

Medications used to treat biotoxicity and neurotoxicity include Cholestyramine (CSM), Welchol, Chemet, Amphotericin B nasal spray, Antibiotics, Anti-yeast remedies, and Anti-fungal compounds. At The Kaplan Center, we also prescribe dietary changes, such as Detox Food Plans, and nutritional supplements including Glutathione, Activated Charcoal, Omega-3 Fatty Acids, Chlorella, Vitamin D, Magnesium, and Probiotics. Before purchasing any over-the-counter nutritional supplements or herbal remedies, it is important to note that:

  1. The quality and efficacy of nutritional supplements can vary widely depending upon the manufacturer and the dosage consumed.
  2. Supplements can interact with other prescription medications, enhancing or undermining the effectiveness of your other medications or even creating new and unexpected problems.

Be sure to ask your physician to provide you with an individualized treatment plan recommending the specific nutritional and herbal products and dosage levels that would most benefit you (given your diagnosis and the other medications you are currently taking).

The Kaplan Center medical team also offers patients who are undergoing detoxification integrative therapies, such as nutritional consultation, acupuncture, osteopathic manipulation, Chinese and American herbal remedies, and recommendations for saunas and exercises. These alternative modalities can provide patients with significant relief from their symptoms and from any side effects of the detoxification process.

What Can I Do Now to Protect Myself and My Loved Ones from Biotoxicity and Neurotoxicity?

The MOST important thing you can do to improve your health and wellbeing is to limit your environmental exposure to toxins by:

  1. Making sure there is no hidden mold in your home (watch the video below for tips on how to keep a healthy environment);
  2. Avoiding high processed foods that contribute to leaky gut – a disruption in the lining of the small intestine that, when present, allows toxins and other unwanted substances to circulate throughout the body;
  3. Eat fresh, organic, and non-GMO whenever possible;
  4. Use green/clean products that do not contain pesticides and other toxic ingredients.

Where Can I Get Additional Information?

For more information about Biotoxicity and Neurotoxicity, we recommend the following sources:



  • Your Guide to Mold Toxins by Gary Rosen, Ph.D. and James Shaller, MD
  • Lose the Weight You Hate by Ritchie Shoemaker, MD
  • Desperation Medicine by Ritchie Shoemaker, MD

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2


Hope, J. (2013). A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins. The Scientific World Journal, 2013.

Sobral, M. M. C., Faria, M. A., Cunha, S. C., & Ferreira, I. M. (2018). Toxicological interactions between mycotoxins from ubiquitous fungi: Impact on hepatic and intestinal human epithelial cells. Chemosphere, 202, 538-548.

Empting, L. D. (2009). Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure. Toxicology and Industrial Health, 25(9-10), 577-581.

Jones, D.C., Miller, G.W. (2008). The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction. Biochemical Pharmacology, Volume 76, Issue 5.

Kwon-Chung, K. J., & Sugui, J. A. (2009). What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? Medical Mycology, 47(Supplement_1), S97-S103

Niide, O., Suzuki, Y., Yoshimaru, T., Inoue, T., Takayama, T., & Ra, C. (2006). Fungal metabolite gliotoxin blocks mast cell activation by a calcium-and superoxide-dependent mechanism: implications for immunosuppressive activities. Clinical Immunology, 118(1), 108-116.

Liew, W. P. P., & Mohd-Redzwan, S. (2018). Mycotoxin: its impact on gut health and microbiota. Frontiers in Cellular and Infection Microbiology, 8, 60.

Reemst K, Noctor SC, Lucassen PJ, Hol EM. The Indispensable Roles of Microglia and Astrocytes during Brain Development. Front Hum Neurosci. 2016;10:566. Published 2016 Nov 8. doi:10.3389/fnhum.2016.00566

Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clin Exp Immunol. 2008;153 Suppl 1(Suppl 1):3-6.


Updated December 20, 2018.

Mycotoxin Illness: Could the air you breathe be making you sick?

Years ago I had a teen patient who presented with nausea, fatigue, weight loss, and cognitive decline. He was so sick, he was missing weeks of school at a time and could not keep up. After a thorough workup, I tested him for mycotoxins, naturally occurring, poisonous substances that are released by certain types of fungi (aka mold), through a urine test. He had 3 different types of mycotoxins, but the level of one certain type of black mold toxin, called trichothecene, was through the roof. He had been living in the basement of his family home. The home was tested and mold was found and remediated. Fortunately, I tested several other family members who were all negative.

However, finding and ridding the environment of the mold was not enough to heal my patient. The toxins had settled into his tissues and because his liver genetically was not clearing them; help was needed. First, he moved out of the house, left high school temporarily, and moved in with another family member in order to remove himself from the toxic environment completely. I then put him on supplements to support the liver detox process, and binding agents to reduce the toxic load through the gut. I also gave him supplements aimed at lowering inflammation in the brain and nervous system. It took several months, but over time he felt better and was able to move back home to finish school. He is now a healthy, happy young man who just left home for college.

I’m happy to report things ended well for my patient. Unfortunately, this type of case is becoming more common, but why?

About a half-century or so ago we lived and worked in homes and buildings that were more open to outdoor air. Over the years our homes and buildings have become more airtight and climate-controlled so that we are now breathing recirculated indoor air as opposed to outdoor air. In addition, instead of being built with plaster our homes and buildings are constructed with porous drywall which when combined with moisture creates a feeding frenzy for mold.

What are molds?

Molds are a group of fungi that produce airborne spores. In nature, molds are decomposers that recycle nature’s organic wastes. In medicine, they are the producers of antibiotics such as Penicillin or drugs, like ergotamines used for migraines. Some molds and fungi, like cheese and mushrooms, are delicacies. However, when certain molds infiltrate our environment, they can wreak havoc on our health.

black mold When there is water intrusion in your home or work environment, such as occurs in a flood or even with a minor water leak, within two days mold spores that have either lain dormant or have come from the outside start to feed off the drywall that is now wet. The mold spores produce mold toxins called mycotoxins. Mycotoxins can thrive under the right conditions (high temperatures and moisture are the major determining factors). These wet areas also become breeding grounds for bacteria that produce toxins called endotoxins. The mold and bacteria infiltrate wall coverings, such as wallpaper and paint, and begin to release volatile organic compounds (VOCs), and this contaminated air circulates through the home or building.

Exposure to high concentrations of mold spores (such as black mold toxin or aspergillosis) over an extended period of time which results in the accumulation of these toxins in the body, is known as “biotoxicity” or “neurotoxicity.”

Questions? Give Us a Call!

703-532-4892 x2

Symptoms of toxicity

The symptoms of toxic inhalation are many. The most common symptoms are respiratory in nature, i.e. sinus congestion, sore throat, cough, wheezing and shortness of breath. This can lead to an autoimmune condition called hypersensitivity pneumonitis.1 However, with continued exposure dysregulation of the immune system and inflammation of the nervous system occurs2,3,4 leading to symptoms such as headaches, fatigue, generalized pain, depression, cognitive issues, rashes, weight gain, and digestive inflammation from ingestion of spores.5

We now understand that there is genetic variability among those who have been exposed to mycotoxins. Some people are genetically capable of clearing low levels of these toxins through the liver detox process and never suffer consequences. Others do not have the ability to clear them and get severely ill, which was the case for my teen patient. This is why the “sick building syndrome” is so controversial – not everyone has the same reaction depending on the degree of exposure. However, given a high enough dose, it can be devastating. In fact, mycotoxins, like trichothecenes from black mold, have been used in biological warfare.6,7

Mycotoxins in food

Mycotoxins can also be found in food as well as airborne. There are over 300 identified types of mycotoxins, but only a small number of these are responsible for contaminating the foods we eat. Contamination can occur at any number of points in the production process – from harvesting and storage to packaging and transportation. Staple crops like wheat, corn, barley, nuts, even coffee beans, are highly susceptible to contamination. The toxin itself cannot be seen by the naked eye so once the toxin is established in a food item it is virtually impossible to eliminate. Aside from being invisible, they are also heat resistant, so they are not affected when food is cooked.

Ochratoxin and aflatoxin, two common types of mycotoxins found in contaminated food, have been shown to cause kidney damage, cancer, and liver failure. 8,9

What you can do

Determining whether you have been exposed to mold toxins is not an easy task. If you suspect mycotoxin illness, let us help you do the appropriate testing and help restore you to good health. The treatment process may include one or more of the options below.

    1. Get tested: Specialized labs that test for both airborne mold toxins and toxins found in food may be ordered.
    2. Talk to an air quality specialist: An indoor air quality specialist can come to your home to determine whether mold is present and what steps are necessary to remediate.

  1. Examine your diet: If exposure appears to be rooted in a food source, such as aflatoxin or ochratoxin, an amylose-free diet (a diet low in sugar, grains, and tubers) may be helpful. Certain nutritional supplements, including Glutathione, N-acetyl Cysteine, Chlorella, Omega-3 Fatty Acids,  Vitamin D, Magnesium and D-Ribose, and binding agents like charcoal, clay or bile acid sequestrants like cholestyramine, may be recommended by your physician to help remove toxins from the body.
  2. Try a complementary therapy: Acupuncture, osteopathic manipulation, and Chinese and American herbal remedies may be helpful in providing relief from symptoms and from any side effects of the detoxification process.

-Lisa Lilienfield, MD

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2