Kaplan Links - Kaplan Center for Integrative Medicine : McLean, Virginia

Dr. Gary Kaplan was a recent guest on the Less Stressed Life Podcast with Christa Biegler, RD.

In this episode, Dr. Kaplan and Christa discuss all things infections, immune system, and inflammation. They take a deep dive into everything from depression to fibromyalgia, give insight into how all of these chronic problems manifest, and how to potentially help them get better.

Discussion highlights:

What drives the inflammatory process
What are strategies for down-regulating microglial activation?
What products can you use for pain, depression, & sleep?
What is neuroinflammation
Unhealthy gut equals unhealthy brain
What is long COVID?
Surprising facts of social isolation
Why it’s important to look at adverse events during childhood
Sleep and its effect on the brain

Praise for Dr. Kaplan’s book – Why You Are Still Sick: How Infections Can Break Your Immune System & How You Can Recover

“Gary Kaplan is not only a pioneer in his field, he’s a badass who is changing the face of medicine. This book holds everything I wish I knew twenty years ago about autoimmunity. It’s an incredible resource for anyone with chronic pain and illness. It will bring hope and health to so many people.”

– Dave Asprey, founder, Bulletproof 360

The daily consumption of curcumin, the active compound in turmeric, can have significant benefits on cognitive health.

According to the National Institutes of Health (NIH), more than 88 million Americans over the age of 65 will be diagnosed with neurodegenerative disease by 2050. The progression of neurodegeneration has been associated with the imbalance between the level of antioxidants and the increased oxidative damage by free radicals to proteins, DNA, and lipids.

Curcumin is a chemical compound found in plants, with anti-bacterial, anti-inflammatory, anti-proliferative, and antioxidant properties. Research has seen an astounding success proving the benefits of curcumin as an antioxidant and anti-inflammatory, with over 7000 articles published in the last two decades. Its neuroprotective properties help prevent free radical damage and calms the inflammatory process at the root of many chronic diseases. Studies have shown it to be effective against many gastrointestinal diseases and metabolic diseases such as diabetes and obesity, certain cancers, cardiovascular disease, and neurodegenerative diseases such as Alzheimer’s. In fact, curcumin has long been suspected to be the reason behind the low rates of Alzheimer’s disease in India, where turmeric spice is widely and frequently used in curry meal preparation.

However, curcumin is unique in that it is not easily absorbed by the body on its own. In order to increase its bioavailability, it must be paired with other compounds, one such example is piperine, a compound found in black pepper.

But for those who don’t have a taste for this beautiful golden spice, supplementation can be key. Research on the supplement Theracurmin* a bioavailable (more easily absorbed by the body) form of curcumin, has shown it contains significantly higher plasma concentration of curcumin than other leading brands of supplements. Clinical studies have also shown it to have benefits in osteoarthritis, muscle fatigue after exercise, and clearing alcohol metabolites. There are on-going clinical trials investigating the effects of Theracurmin on other inflammatory diseases.

A 2019 study on curcumin, led by Dr. Gary Small, director of geriatric psychiatry at UCLA’s Longevity Center, was conducted over an 18 month period and included 40 adults that ranged in age from 51 to 84. Twenty-one randomly selected participants were given twice daily doses of Theracurmin, and the remaining 19 participants were given a placebo. Cognitive assessments were taken every 6 months and curcumin levels were measured at both the start and end of the study. In addition, 30 participants (15 placebo & 15 curcumin) underwent PET scans to measure levels of the proteins amyloid and tau in their brains both at the start of the study and after 18 months. These two proteins are targeted because of their association with neurodegenerative disorders; when accumulated in the brain, they are thought to contribute to the breakdown of neurons which can potentially lead to symptoms of Alzheimer’s disease.

At the end of the study, researchers concluded that the daily intake of Theracurmin resulted in “improved memory performance and attention in non-demented adults.” Based on the PET findings, the study further concluded that “behavioral and cognitive benefits are associated with decreases in plaque and tangle accumulation in brain regions modulating mood and memory.”

While this study was quite small, the results are indeed promising and warrant continued research. Supplementation with a bioavailable form of curcumin, like Theracurmin, shows tremendous potential as a preventative measure against age-related cognitive decline. Furthermore, the effect curcumin has on decreasing existing amyloid plaque and tau accumulation in the brain shows that it may play a significant role in delaying the onset of other neurodegenerative diseases such as Alzheimer’s dementia.

As research continues to reveal turmeric’s bounty of health benefits, including its ability to limit and possibly reverse the damage of inflammation in the brain, it is becoming more and more evident why it is widely referred to as a miracle spice!

Before taking any supplement consult with your physician to discuss any potential side effects.

*Theracurmin®HP is available for purchase from the Kaplan Medical Center Store.