Low-dose naltrexone (LDN) is often confused with naltrexone, which is a pharmaceutical medication used in doses of 50 mg or more to treat alcohol and narcotic pain pill addiction or other opiate abuse. Low-dose naltrexone is a specially compounded capsule of 1.5 to 4.5 mg of naltrexone to help the body combat chronic illness states. It must be specially made by a reliable compounding pharmacist.
LDN acts by reducing inflammation in the brain caused by over-active microglia. Microglia are a type of glial cell of the Central Nervous System (CNS) and an important line of defense. When there is an assault on the CNS, the microglia are activated and release inflammatory substances to destroy the foreign invaders. When the assault is over, the microglia go back into their normal resting state. However, when they react too often – from repeated injury, infection, toxins, traumas, or emotional blows – they can sometimes remain hyper-active keeping the brain in a chronic state of inflammation. Research on LDN suggests that it’s able to suppress the inflammatory response of the microglia.
You can read more about inflammation of the brain and central nervous system as a major component of pain and illness in Dr. Gary Kaplan’s book Total Recovery.
LDN also improves the body’s immune system by blocking opioid receptors which in turn boosts the body’s endogenous endorphins, our natural pain killers and important regulators of cell growth.
You can read more about low-dose naltrexone for auto-immune disorders, and other illnesses at www.lowdosenaltrexone.org.
Because low-dose naltrexone interferes with opiates you cannot continue on narcotic pain medication, but otherwise, it has virtually no side effects and is very well tolerated by most patients. Most people notice an increase in dreaming, and some people notice a bit of sleep disruption during the initial few days of treatment but this improves over time.
– Erika LeBaron, D.O.
Q: Does the Kaplan Center offer low-dose naltrexone treatment for fibromyalgia patients? I know of a number of patients with fibromyalgia, MS, and Hashimoto’s thyroiditis who claim to have seen improvement with LDN.
Erica LeBaron, D.O.: Yes, Low-dose naltrexone is a prescribed therapy for a variety of conditions that we treat here at the Kaplan Center. If you are interested in exploring if low-dose naltrexone may be beneficial for you, call the office and schedule an appointment. I would be happy to talk to you about its possible benefits for your health condition.
Q: I am allergic to NSAIDS, so would I be allergic to this?
Lisa Lilienfield, M.D.: Low-dose naltrexone is not an NSAID (non-steroidal anti-Inflammatory) and therefore any allergy to such would not apply. The higher doses of naltrexone can rarely cause liver toxicity, depression and somnolence, but the low dose naltrexone or LDN has fewer if any side effects in our experience.
Q: The standard dose appears to be 4.5 mg in almost all of the information I can find. There are a few chronic pain MDs in the U.S. that seem to be using higher doses with success — a couple say to go up as high as 10 mg while another one is using it up to 4.5 mgs 3xday with great success for those who do not respond to one dose of 4.5 mgs. Do you have any thoughts on this? What I’ve read is that one should not give up on this medication if not getting benefits at 4.5 mgs.
Lisa Lilienfield, M.D.: At a low dose, the side effects are minimal. Higher doses can cause sleep disturbances and may cause elevation of liver enzymes. Although I don’t usually go higher than 4.5 mg, most likely the doses you are talking about – 10-14 mg – are far from the 50 mg or higher dose that is used to block opioid overdose, and are therefore are probably safe. I don’t see any research on the efficacy of using higher doses, however.
Q: I have read that Low-Dose Naltrexone (LDN) should not be taken by people who have had organ transplants. Does this include an artificial aortic heart valve? Also, does it affect INR levels and should Warfarin dosage need to be readjusted?
Lisa Lilienfield, M.D.: The short answer is that low-dose naltrexone should not be taken by someone on immunosuppressant drugs because it boosts the immune system by stimulating the body’s own endorphins. There are no known interactions with Coumadin but it is always a good idea to check the INR more often when starting a new medication. Therefore if someone has a valve replacement, yet is not on an immunosuppressant, LDN should be safe.
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