Tag Archive for: toxicity

Posts

Losing your mind or are you sick?

“I Think I’m Losing My Mind”: When Treating Tick-Borne Illness Feels Worse Before It Gets Better

/in , , /by

She’s 23. Bright, motivated, kind and always eager to smile. She came to our office after years of searching for answers to her fatigue, body aches, temperature swings, and lightheadedness that started without warning.

Testing eventually revealed she was dealing with Babesia, one of the lesser-known but highly impactful tick-borne co-infections. We started a targeted treatment plan that included antimicrobials, detox support, acupuncture and mitochondrial nutrients. In the first few weeks, she felt hopeful, after having an occipital nerve block done, her headaches were less frequent, she had less body pain and her energy had started to return.

But then something changed.

When she was weeks into her protocol, her mom called the office one Monday morning, worried. Her daughter had become withdrawn, anxious and couldn’t sleep.. She said she felt “like I’m going crazy”. Her heart raced at night. She had dark, intrusive thoughts that made no sense to her. And worst of all, she had stopped her medication without checking in because she felt like she just couldn’t swallow anymore pills—afraid that the treatment was making her worse.

It’s a story I hear often.

What Was Happening?

The medications to kill the parasitic Babesia caused an overall inflammatory response of the brain.

She wasn’t losing her mind. The process of die-off reaction can trigger a wave of inflammation and neurotoxicity—especially in sensitive patients or when infections like Babesia are involved.

Babesia in particular is a red blood cell parasite that releases pro-inflammatory molecules, affects oxygen delivery, and can trigger severe mood and neurologic symptoms. Inflammatory cytokines can cross the blood-brain barrier, activating microglia (the brain’s immune cells) and producing symptoms like:

  • Panic and paranoia
  • Intrusive or obsessive thoughts
  • Nightmares and air hunger
  • Brain fog, rage, or emotional volatility

These are not just mental health concerns—they’re signs of neuroinflammation. And they are treatable—with the right tools and support.

What Helped Her?

Luckily, her family saw changes and brought her back in. She cried when we explained what was happening—but this time, with relief. She wasn’t broken. Her brain was inflamed, and her nervous system was overwhelmed by the die-off. We sat down together and made a plan:

  • Paused medications for a few days to let the inflammation calm down
  • Restarted treatment at a lower dose, with pulsing to avoid overload
  • Burbur and pinella drops in water to help detox
  • Continuing her glutathione and binders to support detox
  • Doing an IV with glutathione in the clinic to help detox her body faster
  • Encouraged her to take her magnesium, L-theanine, and omega-3s to support her brain
  • Encouraged gentle movement, hydration with electrolyte drinks, acupuncture, salt baths and infrared sauna

But most importantly—we agreed that she would not stop treatment without calling us first. Because when you’re navigating a complex illness, especially one that hides in the nervous system, staying connected to your care team is as important as any prescription.

The Takeaway

Communication is the key to successful treatment…. Don’t assume it means you’re regressing—or broken. It may be a signal that your body is fighting hard—and just needs help navigating the process. Pause. Reach out. Let’s reassess and adjust the plan.

Tick-borne illnesses can affect every part of us—the body, the brain, the mood, and the spirit. But with the right support, healing is possible. And more often than not, you are far stronger and more resilient than you realize.

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

mold toxicity, mycotoxin illness

Mycotoxin Illness: Could the Air You Breathe Be Making You Sick?

/in /by

Years ago I had a teen patient who presented with nausea, fatigue, weight loss, and cognitive decline. He was so sick, he was missing weeks of school at a time and could not keep up. After a thorough workup, I tested him for mycotoxins, naturally occurring, poisonous substances that are released by certain types of fungi (aka mold), through a urine test. He had 3 different types of mycotoxins, but the level of one certain type of black mold toxin, called trichothecene, was through the roof. He had been living in the basement of his family home. The home was tested, and mold was found and remediated. Fortunately, I tested several other family members who were all negative.

However, finding and ridding the environment of the mold was not enough to heal my patient. Toxins had settled into his tissues and because his liver genetically was not clearing them help was needed. First, he moved out of the house, left high school temporarily, and moved in with another family member in order to remove himself from the toxic environment completely. I then put him on supplements to support the liver detox process, and binding agents to reduce the toxic load through the gut. I also gave him supplements aimed at lowering inflammation in the brain and nervous system. It took several months, but over time he felt better and was able to move back home to finish school. He is now a healthy, happy young man who just left home for college.

I’m happy to report things ended well for my patient. Unfortunately, this type of case is becoming more common, but why?

About a half-century or so ago we lived and worked in homes and buildings that were more open to outdoor air. Over the years our homes and buildings have become more airtight and climate-controlled so that we are now breathing recirculated indoor air as opposed to outdoor air. In addition, instead of being built with plaster our homes and buildings are constructed with porous drywall which when combined with moisture creates a feeding frenzy for mold.

What are molds?

Molds are a group of fungi that produce airborne spores. In nature, molds are decomposers that recycle nature’s organic wastes. In medicine, they are the producers of antibiotics such as Penicillin or drugs, like ergotamines, used for migraines. Some molds and fungi, like cheese and mushrooms, are delicacies. However, when certain molds infiltrate our environment, they can wreak havoc on our health.

black mold

When there is water intrusion in your home or work environment, such as occurs in a flood or even with a minor water leak, within two days mold spores that have either lain dormant or have come from the outside start to feed off the drywall that is now wet. The mold spores produce mold toxins called mycotoxins. Mycotoxins can thrive under the right conditions (high temperatures and moisture are the major determining factors). These wet areas also become breeding grounds for bacteria that produce toxins called endotoxins. The mold and bacteria infiltrate wall coverings, such as wallpaper and paint, and begin to release volatile organic compounds (VOCs), and this contaminated air circulates through the home or building.

Exposure to high concentrations of mold spores (such as black mold toxin or aspergillosis) over an extended period of time which results in the accumulation of these toxins in the body, is known as “biotoxicity” or “neurotoxicity.”

Questions? Give Us a Call!

703-532-4892 x2

Symptoms of mold toxicity

The symptoms of toxic inhalation are many. The most common symptoms are respiratory in nature, i.e. sinus congestion, sore throat, cough, wheezing and shortness of breath. This can lead to an autoimmune condition called hypersensitivity pneumonitis. However, with continued exposure, dysregulation of the immune, nervous, and endocrine systems can occur leading to a range of symptoms such as headaches, fatigue, generalized pain, depression, cognitive issues, rashes, weight gain, and digestive inflammation from ingestion of spores.

We now understand that there is genetic variability among those who have been exposed to mycotoxins. Some people are genetically capable of clearing low levels of these toxins through the liver detox process and never suffer consequences. Others do not have the ability to clear them and get severely ill, which was the case for my teen patient. This is why the “sick building syndrome” is so controversial – not everyone has the same reaction depending on the degree of exposure. However, given a high enough dose, it can be devastating. In fact, mycotoxins, like trichothecenes from black mold, have been used in biological warfare.

Mycotoxins in food

Mycotoxins can also be found in food as well as airborne. There are over 300 identified types of mycotoxins, but only a small number of these are responsible for contaminating the foods we eat. Contamination can occur at any number of points in the production process – from harvesting and storage to packaging and transportation. Staple crops like wheat, corn, barley, nuts, even coffee beans, are highly susceptible to contamination. The toxin itself cannot be seen by the naked eye so once the toxin is established in a food item it is virtually impossible to eliminate. Aside from being invisible, they are also heat resistant, so they are not affected when food is cooked.

Ochratoxin and aflatoxin, two common types of mycotoxins found in contaminated food, have been shown to cause kidney damage, cancer, and liver failure.

How we can help | Treating mold toxicity

Determining whether you have been exposed to mold toxins is not an easy task. If you suspect mycotoxin illness, we can help you with the appropriate testing and restore you to good health. The treatment process may include one or more of the options below.

  1. Get tested: Specialized labs that test for both airborne mold toxins and toxins found in food may be ordered for you.
  2. Talk to an air quality specialist: We recommend speaking to an indoor air quality specialist. They can come to your home to determine whether mold is present and what steps are necessary to remediate.
  3. Examine your diet: If exposure appears to be rooted in a food source, such as aflatoxin or ochratoxin, an amylose-free diet (a diet low in sugar, grains, and tubers) may be helpful. Certain nutritional supplements, including Glutathione, N-acetyl Cysteine, Chlorella, Omega-3 Fatty Acids,  Vitamin D, Magnesium and D-Ribose, and binding agents like charcoal, clay or bile acid sequestrants like cholestyramine, may be recommended by your physician to help remove toxins from the body.
  4. Try a complementary therapy: Acupuncture, osteopathic manipulation, and Chinese and American herbal remedies may be helpful in providing relief from symptoms and from any side effects of the detoxification process.

-Lisa Lilienfield, MD

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

References

Learn About Hypersensitivity Pneumonitis

Mycotoxins, World Health Organization; Fact Sheet

Immune and Nervous Systems Interaction in Endocrine Disruptors Toxicity: The Case of Atrazine

Impact of Pesticides on Immune-Endocrine Disorders and Its Relationship to Cancer Development.

Impact of mycotoxins on the intestine: are mucus and microbiota new targets?

CBRNE – T-2 Mycotoxins

Facts about Stachybotrys chartarum

Occurrence, Toxicity, and Analysis of Major Mycotoxins

Ochratoxins in Wines: A Review of Their Occurrence in the Last Decade, Toxicity, and Exposure Risk in Humans

 

This article was originally published in December 2017. It was reviewed and updated in April, 2024.

Toxicity disorders can affect mood and overall health.

Living with Chronic Pain and Illness? You May Be Suffering from a Toxicity Disorder

/in /by

Anyone can be at risk of being exposed to and affected by harmful toxins. Exposure can occur in your own home, at work, or while traveling. The good news is that for most people the liver is able to break down these toxins so they can pass through the intestines and be excreted from the body. However, approximately 20 percent of the general population lacks the enzymes needed to break down toxins for elimination, leaving this group particularly vulnerable. Instead of being excreted, harmful toxins can be reabsorbed through the lining of the intestines back into the body. The body then sequesters them wherever it can, damaging the muscle tissue, nerves, and nervous tissues in those “holding areas.”

You can be exposed to toxins in the following ways:

  • By ingesting contaminated food, beverages, and water.
  • By inhaling aerosolized particles in the air.
  • Through direct contact with mucus from eyes, nose, mouth, etc…
  • Through direct contact with the skin

If you think you have been exposed to toxins that are affecting your health, call and speak with a nurse today: 703-532-4892, ext. 2.

CALL NOW

Not all toxins are the same

Biotoxins

Biotoxins are toxic substances from biological sources, like plants, bacteria, molds, and animals that alter the body’s normal biological systems that manage digestion, respiration, circulation, joint flexibility, etc. When this happens the resulting condition is called biotoxicity.

Neurotoxins

Neurotoxins affect the nervous system and disrupt the normal functioning of neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. This is called neurotoxicity.

Neurotoxins can be of natural or manmade origin. For example, neurotoxins can be found in molds, heavy metals (lead, mercury), and insect bites, as well as in pesticides, food preservatives (aspartame), and substances used in chemotherapy, radiation treatments, and drug therapy, among other things.

Mycotoxins

Mycotoxins are a type of biotoxin and the byproducts of fungi (molds) that can have toxic effects on humans and animals. Aspergillus, Penicillium, Stachybotrys, and Fusarium are some of the more common fungi that produce the following toxic offspring: Aflatoxins, Gliotoxins, Ochratoxins, and Trichothecenes.

Mycotoxins are primarily found in:

  1. Structures: In water-damaged homes and buildings
  2. Food: Common contaminants of human food products, like wine, coffee beans, nuts, cereal grains (wheat, corn, barley, etc…) and animal feed. They can also enter the food chain through food products, such as milk, meat, and eggs, obtained from animals that are fed mycotoxin-contaminated feed.

Questions? Give Us a Call!

703-532-4892 x2

Health effects of mold toxicity

Mycotoxins and leaky gut

The job of the small intestine is to allow nutrients to pass through its lining so they can be absorbed into the bloodstream and circulated to all the major organs. But it also works as a filter to prevent foreign or toxic substances from entering the bloodstream. When there is damage to the lining and foreign substances are able to penetrate this is called leaky gut or intestinal permeability. Since we now know that 70-80% of our immune system is located in our gut it is not surprising that the effects of leaky gut can be serious.

Researchers investigated the presence of mycotoxins in the gastrointestinal tract and concluded that Candida Albicans, one of the pathogenic fungi residing in the intestines, harmless in small amounts, starts producing gliotoxins if its number outgrows the other beneficial bacterial species in the gut, causing a myriad of neurological and gastrointestinal symptoms. Exposure to Candida Albicans and other mycotoxins results in:

  • Disrupting intestinal integrity causing dysbiosis (imbalance in gut bacteria) or leaky gut
  • Disrupting the microbiome
  • Suppressing the local immune response in the intestines

Neurocognitive symptoms

In the brain, the glial cells (microglia and astrocytes) are part of an interactive network of cells that work to protect the nerves and brain from damage and ensure their proper development. Research shows that exposure to mycotoxins can suppress and impair their proper functioning, putting an individual’s cognitive development and/or function at risk.

A research study that measured IQ scores in 277 six-year-old children, who were exposed to indoor mold for more than 2 years, showed IQ deficits of approximately 10 points using a scale of intelligence, exemplifying the dangers of exposure on cognitive development in early childhood.

Other classic neurologic disorders that result from mycotoxin exposure include pain syndromes and depression, movement disorders, delirium, dementia, and balance and coordination disorders.

Mold toxicity is one of the major toxicity conditions we see at the Kaplan Center. Over the years we have gained a better understanding of the pathophysiology, or disease process, of environmental toxicity and have developed a successful treatment protocol. We have been delighted to see an extraordinary resolution of symptoms in about 50 percent of patients, and notable improvement in another 40 percent. Obviously, the protocol is not a cure-all, but it has helped a number of patients feel significantly better.

Toxcity disorders can cause headaches and many other pain symptoms.What Are Common Symptoms of Toxicity Disorders?

The following is a list of symptoms that may indicate the presence of biotoxins or neurotoxins in your body:

– Joint Pain – Muscle Pain – Chronic Headaches
– Fatigue – Digestive Problems – Decreased Ability to Focus
– Sleep Problems – Decreased Libido – Weight gain / Obesity
– Depression – Anxiety – Mood Swings
– Poor Memory – Irritability – Wheezing

Are the Symptoms of Biotoxicity & Neurotoxicity Similar to Those of Other Disease Conditions?

Yes. Because the symptoms of biotoxicity and neurotoxicity are similar to those of other diseases, toxicity disorders are often overlooked as the underlying cause of illness.

Can I Be Tested for Biotoxicity or Neurotoxicity?

If you are experiencing any of the symptoms listed above, and, especially if your condition has not responded to conventional medical treatment, the Kaplan Center recommends the following steps:

  1. (And most important!) Take the time to talk with your doctor about your history of exposure to environmental toxins.
  2. Take an On-line Visual Contrast Sensitivity Test (VCS). This non-invasive test is a sensitive indicator of your exposure to a variety of toxins. There are a number of online resources that offer this test for a small fee.
  3. Undergo genetic testing (HLA-testing) to determine if your body has the enzymes necessary to breakdown biotoxins.
  1. Undergo advanced testing. There are a variety of tests that can detect the presence of toxins (including mycotoxins, heavy metals, infectious sources, food additives, pesticides, and other toxic chemicals). Talk to your physician about which test(s) may be most appropriate for you, based on your history of exposure
  2. Test for leaky gut. When the protective filtering system within the intestines is compromised, it is known as Intestinal Permeability – or leaky gut. Toxins and other substances that would normally have been kept within the gastrointestinal (GI) tract and eliminated are now able to get into the bloodstream and circulate throughout the body.

Treating Biotoxicity and Neurotoxicity

There are a variety of treatments available to patients suffering from biotoxicity or neurotoxicity disorders. If the underlying cause of your pain or illness is biotoxicity or neurotoxicity, your treatment plan must include a detoxification regime, or your overall recovery is likely to be incomplete and slower than it needs to be. Your treatment plan should be individually tailored after consideration of your overall medical history, your current symptoms, your genetic makeup, your history of exposure to toxins, and your lifestyle. In essence, a detoxification regime is designed to “draw out” toxins from whichever tissue they have been stored and “bind” the toxins at the molecular level so they can finally be eliminated from the body; this is typically done with binders and anti-fungal medications.  We also prescribe dietary changes, such as Detox Food Plans, and nutritional supplements including Glutathione, Activated Charcoal, Omega-3 Fatty Acids, Chlorella, Vitamin D, Magnesium, and Probiotics. Before purchasing any over-the-counter nutritional supplements or herbal remedies, it is important to note that:

  1. The quality and efficacy of nutritional supplements can vary widely depending upon the manufacturer and the dosage consumed.
  2. Supplements can interact with other prescription medications, enhancing or undermining the effectiveness of your other medications or even creating new and unexpected problems.

The Kaplan Center medical team also offers integrative therapies, such as nutritional consultation, acupuncture, osteopathic manipulation, Chinese and American herbal remedies, and recommendations for saunas and exercises. These alternative modalities can provide patients with significant relief from their symptoms and from any side effects of the detoxification process.

What Can I Do Now to Protect Myself and My Loved Ones from Biotoxicity and Neurotoxicity?

The MOST important thing you can do to improve your health and wellbeing is to limit your environmental exposure to toxins by:

  1. Making sure there is no hidden mold in your home (watch this video featuring David Young MPH, an Indoor Health Specialist, for tips on how to keep a healthy environment);
  2. Avoiding high processed foods that contribute to leaky gut – a disruption in the lining of the small intestine that, when present, allows toxins and other unwanted substances to circulate throughout the body;
  3. Eating fresh, organic, and non-GMO whenever possible;
  4. Using green/clean products that do not contain pesticides and other toxic ingredients.

Where Can I Get Additional Information?

For more information about Biotoxicity and Neurotoxicity, we recommend the following sources:

Websites:

Books:

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

References

Hope, J. (2013). A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins. The Scientific World Journal, 2013.

Sobral, M. M. C., Faria, M. A., Cunha, S. C., & Ferreira, I. M. (2018). Toxicological interactions between mycotoxins from ubiquitous fungi: Impact on hepatic and intestinal human epithelial cells. Chemosphere, 202, 538-548.

Empting, L. D. (2009). Neurologic and neuropsychiatric syndrome features of mold and mycotoxin exposure. Toxicology and Industrial Health, 25(9-10), 577-581.

Jones, D.C., Miller, G.W. (2008). The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction. Biochemical Pharmacology, Volume 76, Issue 5.

Kwon-Chung, K. J., & Sugui, J. A. (2009). What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? Medical Mycology, 47(Supplement_1), S97-S103

Niide, O., Suzuki, Y., Yoshimaru, T., Inoue, T., Takayama, T., & Ra, C. (2006). Fungal metabolite gliotoxin blocks mast cell activation by a calcium-and superoxide-dependent mechanism: implications for immunosuppressive activities. Clinical Immunology, 118(1), 108-116.

Liew, W. P. P., & Mohd-Redzwan, S. (2018). Mycotoxin: its impact on gut health and microbiota. Frontiers in Cellular and Infection Microbiology, 8, 60.

Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021 Mar 9;13(3):886. doi: 10.3390/nu13030886. PMID: 33803407; PMCID: PMC8001875.

Reemst K, Noctor SC, Lucassen PJ, Hol EM. The Indispensable Roles of Microglia and Astrocytes during Brain Development. Front Hum Neurosci. 2016;10:566. Published 2016 Nov 8. doi:10.3389/fnhum.2016.00566

 

This article was originally published in December, 2018 and reviewed in March, 2024.

Human_Optimization_Podcast

LISTEN NOW: Why You Are Still Sick

/in , /by

Dr. Kaplan was a recent guest on the Human Optimization Podcast with host Lisa Pitel Killah, BCHHP, FDN-P, hTMAP.

In this podcast, Dr. Kaplan and Lisa discuss

  • How inflammation influences chronic pain and depression/anxiety symptoms
  • What are “microglia”, how they influence inflammation, and what sets them off
  • How stress and adverse events in childhood can impact your immune system
  • What it means to have a brain on fire
  • The importance of finding the root cause(s) of your symptoms to get to the bottom of why you are still sick
  • Supplements and medications that are effective in treating long COVID and other chronic illnesses
  • The importance of a healthy gut and good sleep hygiene, and so much more!

Listen now: Episode #77: Why You Are Still Sick

 

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

Living An Anti-Inflammatory Lifestyle

LISTEN NOW: Living an Anti-Inflammatory Lifestyle with Dr. Gary Kaplan

/in , /by

Uncover the complexities of inflammation in this informative episode of Wild Health Podcast featuring Dr. Mike Stone and special guest Dr. Gary Kaplan, DO.

In this episode, “Living an Anti-Inflammatory Lifestyle”, you’ll learn about:

  • practical interventions aimed at combating inflammation.
  • effective lifestyle adjustments and avenues for testing.
  • the role of narcolepsy, sleep apnea, and the role of meditation in sleep quality – and how they are all linked to inflammation.
  • the connection between nutrition and inflammation and actionable steps to identify inflammation-inducing foods
  • how supplementation can address inflammation head-on.
  • the profound influence of inflammation on brain function.
  • inflammations impact on the mind.

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

Dealing with Anxiety

8 Commonly Overlooked Causes Of Anxiety and Depression

/in , , /by

With the right treatment, people seeking relief from depression or anxiety can live happy, productive lives. But if you’re one of the many Americans seeking relief from depression or anxiety, you’re no doubt aware of just how elusive successful treatment can be. It is estimated that as many as 30% of depressed patients do not respond to treatment, raising an important question: could it be that we’re thinking about — and therefore treating — these conditions in the wrong way?

A growing body of research suggests that depression and anxiety might not be mental disorders in and of themselves, but rather symptoms of a physical inflammation stemming from increased microglial activity in the brain. Microglia are the immune cells of the Central Nervous System (CNS) and are responsible for producing inflammatory chemicals in response to infection or other CNS damage.

This gives the medical community and those living with these debilitating conditions new hope. In thinking about depression and anxiety as symptoms, we’re afforded new insights into potential root causes, as well as alternative methods of treatment.

Here are eight often-overlooked causes of depression and anxiety that you should consider:

1. Celiac disease or gluten intolerance.

About 1% of Americans have celiac disease, an autoimmune disorder caused by the body’s negative reaction to gluten, the protein found in wheat, barley and rye. And gluten intolerance — also called non-celiac gluten sensitivity — is estimated to impact six times as many Americans.

While we don’t yet understand the mechanism of gluten intolerance in the body, the impact can be very similar to that seen with celiac disease. While intestinal complaints are most common, research is showing that some people with these conditions may, in fact, present with anxiety and depression as the only symptoms.

You can test for celiac disease with a simple blood test. The only way to test for gluten intolerance is to go gluten-free for six weeks and watch for any improvement. (Before making any major dietary changes, make sure to consult your provider or a registered dietitian.)

2. Sleep apnea.

There are two types of sleep apnea. Obstructive sleep apnea is the more common form and occurs when the soft tissue in the back of the throat collapses, thereby blocking the airway during sleep. Central sleep apnea, although not as common, is a result of the brain forgetting to tell the body to breathe. Studies confirm the relationship between sleep apnea and depression.

If you get plenty of sleep but never feel quite rested, or you find yourself often nodding off, a first step you can take is to answer the 8 questions on the Epworth Sleepiness Scale. If your score is equal to or higher than 10, the results should be discussed with your provider.

3. Lyme disease.

Lyme and other tick-borne diseases are becoming increasingly prevalent. While the most common symptom is joint pain, these diseases can also be associated with depression and anxiety disorders (affective disorders).

This link between Lyme disease and neuropsychiatric disease was first documented in 1994 in the American Journal of Psychiatry and has been widely documented since, but the potential connection is frequently overlooked when diagnosing those with psychiatric illness. If you are suffering from chronic pain and a mental disorder, this diagnosis should be considered.

Questions? Give Us a Call!

703-532-4892 x2

4. Unhealthy diet.

A study published in PNAS (Proceedings of the National Academy of Sciences of the United States of America) confirmed that “…frequent fried food consumption is strongly associated with a higher risk of anxiety and depression.”

On the other hand, eating a diet high in omega-3 fatty acids (fish oils, walnuts, and flaxseed) and antioxidants (colorful fruits, berries, and greens including spinach, broccoli, and collards) can help provide the brain with the nutrients it needs to repair free radical damage and optimize function.

5. Thyroid disease.

Both an under-functioning thyroid (hypothyroidism) and an over-functioning thyroid (hyperthyroidism) can present as depression or anxiety — not to mention other symptoms like weight changes and exhaustion. If you suffer from depression or anxiety, you may wish to have your thyroid hormone levels checked to rule out any disorder.

6. Medications.

It’s also possible that regular medications may be causing or worsening your depression or anxiety. Beta-blockers used to treat high blood pressure are known to cause depression, and acne-fighting Accutane, birth control pills, and even statins all list depression as a possible side effect.

If you take medication regularly, I recommend talking with your provider about the chances that your medication is bringing you down or making you anxious.

7. Toxic mold exposure.

Exposure to certain indoor molds can result in a wide range of symptoms, including depression, ADHD, difficulty concentrating, fatigue, chronic sinus infections, and various pulmonary and neurologic issues. If you fear that you’ve been exposed to indoor molds, it’s critical that you speak with a physician who is familiar with mold toxicity disorder.

8. Coffee.

Several studies have demonstrated a link between coffee consumption and heightened anxiety. While most people can tolerate one to two cups of coffee per day without issue, if you are prone to anxiety, you may want to rethink your morning pick-me-up. Try cutting out coffee altogether for at least two months and observe whether or not your mental state changes as a result.

This article first appeared in Dr. Kaplan’s column on MindBodyGreen.com in September 2015. It was reviewed and updated in May 2023.

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

Additional Resources

Harding CF, Pytte CL, Page KG, Ryberg KJ, Normand E, Remigio GJ, DeStefano RA, Morris DB, Voronina J, Lopez A, Stalbow LA, Williams EP, Abreu N. Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunction. Brain Behav Immun. 2020 Jul;87:218-228. doi: 10.1016/j.bbi.2019.11.006. Epub 2019 Nov 18. PMID: 31751617; PMCID: PMC7231651.

Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The Safety of Ingested Caffeine: A Comprehensive Review. Front Psychiatry. 2017 May 26;8:80. doi: 10.3389/fpsyt.2017.00080. PMID: 28603504; PMCID: PMC5445139.

dark_chocolate

The Dark(er) Side of Dark Chocolate

/in , , /by

While we’ve come to love dark chocolate and all its benefits, a Consumer Reports (CR) article published in December 2022 found that there are reasons to be careful and evaluate what we’re consuming. Testing results showed that 23 of 28 bars had potentially harmful levels of either cadmium or lead or both when eating one ounce per day. Click here to view the article and CR’s findings.

About CR’s findings…

Consumer Reports’ researchers found that when testing for the presence of certain heavy metals, many popular brands of dark chocolate had dangerous levels of both lead and cadmium.

Lead and cadmium are environmental contaminants (along with mercury, arsenic, iron, aluminum, and several others) also referred to as heavy metals. Limited exposure is not typically harmful, but over time, repeated exposure can result in a toxic accumulation in the body and a variety of health issues.

Over the last fifty years, the Food and Drug Administration (FDA) has worked diligently to reduce the levels of toxins found in food, particularly in foods prepared for infants and children and pregnant women. There are no specific federal limits on the amount that most foods can contain, and the onus is on manufacturers to minimize or prevent exposure, however, the FDA may act in response to reports of elevated levels. Click here to read more about the FDA and environmental contaminants.

Does dark chocolate have real health benefits?

Dark chocolate has long been identified as a “super-food” and for good reason, the key is in the cocoa. Here are some of the proven benefits of dark chocolate:

  • The cocoa in dark chocolate contains antioxidants that fight dangerous free radicals in your body.
  • The plant-derived flavanols in dark chocolate have been shown to reduce blood pressure.
  • Dark chocolate increases the elasticity of the blood vessels.
  • Dark chocolate has anti-inflammatory compounds which can reduce inflammation of cardiovascular tissue.
  • Reduces LDL (low-density lipoprotein) cholesterol.

In addition, a 2020 study published in Frontiers in Plant Science found that the flavan-3-olds found in dark chocolate are helpful in preventing the replication of the Covid-19 virus. Flavan-3-olds are a subtype of flavonoids (compounds with antioxidant properties) can also be found in certain teas and colorful fruits and vegetables.

Questions? Give Us a Call!

703-532-4892 x2

So, while there are reasons to be cautious, there are also proven benefits. So it cutting out dark chocolate the answer? Not necessarily. We make some recommendations below to help lower your risk of exposure.

To help lower your risk of exposure we recommend that you:

  • choose brands that have better safety standards.
  • cut back on the frequency and amount of dark chocolate you eat, especially if you eat it every day.
  • make sure you eat a wide variety of fruits and vegetables which contain many of the same benefits as dark chocolate.

Diagnosing and treating toxicity

When toxins enter the body, they hide out in “holding areas” in our tissue and can cause widespread inflammation. Some people are better at breaking down toxins and eliminating them, while others are not. Symptoms of toxicity can include cognitive issues, depression and mood swings, sleep disturbances, headaches, joint pain, or digestive issues.

If you believe you have been exposed to toxins and are experiencing symptoms that cannot be attributed to a specific health diagnosis, we encourage you to consider getting tested. Living with toxicity can not only cause its own symptoms but can slow down recovery from an existing health condition.

There are a variety of specialized tests that can detect the presence of toxins (including mycotoxins, heavy metals, infectious sources, food additives, pesticides, and other toxic chemicals). If a diagnosis is confirmed, medications, dietary changes, and nutritional supplements are the best methods of treatment. For more information, click here.

 

@consumerreports Our scientists measured the amount of heavy metals in 28 dark chocolate bars. Measurable amounts of cadmium and lead were detected in all of them. Learn more through the link in our bio. #foodtiktok #foodtok #foodsafety #darkchocolate ♬ original sound – Consumer Reports

Additional references:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950163/

https://pubmed.ncbi.nlm.nih.gov/36452001/

https://pubmed.ncbi.nlm.nih.gov/11790962/

https://pubmed.ncbi.nlm.nih.gov/28439881/

http://www.ncbi.nlm.nih.gov/pubmed/21559039

strengthen_your_immune_system

5 Ways to Strengthen a Weakened Immune System

/in , /by

We have heard it a million times before. One of the keys to maintaining a robust immune system is lowering inflammation. An article published on MDLinx online mentions several ways we may unknowingly be weakening our immune system. Factors discussed in the article include:

  1. Eating foods that contain too much fructose
  2. High daily stress levels
  3. Lack of adequate sleep (…starting to sound familiar?)
  4. Sunburn
  5. Loneliness

None of the items above are particularly surprising – we know what’s good for our bodies (not fructose!) and our minds (definitely not stress) – so how does the immune system become compromised?

When inflammation goes awry

Inflammation is one of our body’s defense mechanisms; it’s a normal, healthy, and necessary biological function. When the body identifies a threat or a foreign invader, it releases inflammatory chemicals to initiate the repair process. But under repeated “assaults” it can remain in a state of heightened inflammation and this is when the trouble begins.

When the body is constantly producing inflammatory chemicals, the function of the Central Nervous System which controls most bodily functions is undermined and can compromise other systems like the immune system. When the immune system is weakened, the cells that are meant to help fight infection become damaged, and the body’s ability to fight disease is diminished. One can literally get caught in a debilitating cycle of cellular degeneration and dysregulation.

The items mentioned above, as well as any of the following, can contribute to a cycle of sustained inflammation when left untreated:

  • Undiagnosed bacterial or viral infections
  • Exposure to mold or other toxins
  • Physical trauma/concussions
  • Surgery
  • Undiagnosed food intolerance
  • Nutritional deficiencies
  • Anxiety disorders/ PTSD
  • Narcotic medications

Questions? Give Us a Call!

703-532-4892 x2

Reversing the cycle

If you notice that you’re often sick, fatigued, or have frequent digestive issues, it may be a red flag that your immune system is weakened. With a better understanding of how inflammation may be contributing to your condition, the next step is to initiate practices and, if necessary, seek treatments that will calm the inflammatory cycle. Here’s what helps:

  1. TRY AN ELIMINATION DIET. For six weeks, avoid all foods with wheat, soy, milk, and milk products (foods that often trigger allergies or sensitivities that promote inflammation). Eat only fresh fruits, vegetables, brown rice, fish, chicken, and eggs—these foods, in general, are the least likely to cause inflammation. After six weeks, add back one category of food—such as dairy—per week. Note whether these foods have a negative effect on your energy, mood, or level of pain. If so, eliminate that food from your diet entirely.
  2. MEDITATE. A 2020 review looking at the effects of mindfulness meditation on the immune system concluded that “mindfulness meditation appears to be associated with reductions in pro-inflammatory processes, increases in cell-mediated defense parameters, and increases in enzyme activity that guards against cell aging.”
  3. SLEEP. Make adjustments to your sleep environment and aim for at least 7 hours of sleep per night. This is at minimum what your body needs to be able to carry out important repair functions like reducing inflammation, tissue repair, and hormone production.
  4. CUT BACK ON OTC MEDICATIONS. Non-steroidal anti-inflammatory drugs (NSAIDs) like Advil, Motrin, and Aleve can cause gastrointestinal issues like intestinal ulcers and bleeding when taken chronically to manage pain. NSAIDs can also increase the risk of heart attack or stroke in patients with or without heart disease or risk factors for heart disease. Taking pain relievers routinely to manage pain may actually cause your pain to worsen; the body begins to forget how to fight it on its own. Use OTC medications sparingly and try alternative therapies such as yoga and acupuncture as well as anti-inflammatory supplements* like turmeric.
  5. WHEN YOU NEED TO SEE A PHYSICIAN, CONSIDER ONE WHO PRACTICES FUNCTIONAL MEDICINE (FM). In looking for clues that may be contributing to symptoms of illness or disease a Functional Medicine physician will systematically assess and optimize six major areas of health, including the immune system. In doing so, FM doctors have a more complete picture of one’s overall health and underlying conditions or deficiencies that may be causing inflammation. FM doctors utilize several modes of treatment, including stress reduction & management, mind-body tools, improving nutrition, healing your gut, supporting detoxification, exercise, acupuncture, herbs/botanicals, IV Therapy, supplements, manual medicine, and when needed, medication.

*Ask your physician about any potential side effects or interactions before taking any new medicinal herbs and supplements.

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

overlooked causes of migraines

5 Overlooked Causes Of Migraine Headaches

/in , /by

With migraine headaches, it’s important to look beyond the symptom to target the disease.

Lindsay was 23 years old, fresh out of college, and working at her dream job in Washington, D.C., as a congressional aid. Working in Congress, 10-hour days are the norm and for Lindsey, typically the first to arrive in the morning and last to leave in the evening – that was a short day.

She was in charge not only of the Senator’s schedule but also required to be at his side taking notes at all his meetings, as well as keeping him informed as to who he was meeting with and why.

Young, energetic, with an excellent memory and a gift for attention to detail, Lindsay was a rapidly rising star in the highly competitive world of Capitol Hill. When we met, Lindsay was clearly intelligent, completely charming, and terrified that everything she had achieved could be completely undone by progressively crippling migraines.

She had suffered from migraines since she was 16 and had seen several physicians, including neurologists. Yet despite trials of numerous medications, the headaches had become more frequent and debilitating within the last year.

According to the American Migraine Foundation, 1 billion Americans of all ages suffer from migraines. Women are disproportionately affected, impacting approximately 1 in 5 American women versus 1 in 16 men.

For most migraine sufferers, the attacks occur one to two times a month or less, but about 4 million people agonize with a migraine 15 days or more a month. Migraine headaches are regarded as one of the top 20 of the world’s most debilitating medical illnesses.

Most physicians treat migraines as a disease, when in fact, they may be a symptom. By this, I mean that if you go to your doctor complaining of headaches that are diagnosed as migraines, the appointment typically ends with a prescription for medications to either prevent the occurrence of the headache or treat the acute headache, with little if any testing.

It’s rare for any consideration to be given to why you get the headaches. But, if you can find the underlying cause, you have a much better chance of finding the cure.

Questions? Give Us a Call!

703-532-4892 x2

Here are five frequently overlooked causes of migraine headaches:

1. Celiac disease and gluten intolerance

Celiac disease is an autoimmune disease to gluten, a protein found in the grains wheat, barley, and rye. About 1% of the population suffers from Celiac disease and unfortunately, it’s estimated that over 80% of the people with Celiac disease are undiagnosed.

Gluten intolerance (GI) affects about 6% of the American population. GI, while not associated with the damage to the lining of the small intestines as seen in Celiac disease, can make you almost as sick as Celiac disease.

Because eating grains causes Celiac disease and GI, we tend to think that this is an intestinal problem and expect to see people complaining of abdominal symptoms such as bloating, diarrhea and abdominal pain. In fact, both these diseases can present with minimal or no gastrointestinal symptoms and a large number of other symptoms including migraines, peripheral nerve damage, seizures, anxiety disorders, depression, and even schizophrenia. This was documented in an excellent review published in 2012.

You can screen for Celiac disease with a simple blood test, but we do not have any reliable testing for GI as of yet. Treatment for both conditions is the elimination of all gluten-containing foods from your diet.

Questions? Give Us a Call!

703-532-4892 x2

2. Magnesium deficiency

This may play a role in the occurrence of migraines in up to 50% of the people who suffer from this condition. (An excellent summary of this research was published in 2012.)

Magnesium is essential for a wide range of functions in the body and unfortunately, it’s easy to become deficient in magnesium and difficult to measure with a blood test.

Low nutritional intake, excess consumption of coffee, sodas, and alcohol, chronic stress, chronic illness, and intestinal problems (such as Celiac disease creating problems with absorption of magnesium) can all lead to deficiency.

The foods highest in magnesium, such as halibut, mackerel, boiled spinach, bran breakfast cereal, and nuts such as almonds, cashews, and pumpkin seeds, are not foods that typically make up much of our diets.

I encourage my patients suffering from migraines to make the necessary dietary changes and to supplement with between 250 and 500mg of magnesium a day.

One of the side effects of taking magnesium is diarrhea. If you develop diarrhea while taking magnesium, decrease the dose or try switching the type of magnesium you are taking.

We also treat many of our migraine patients with IV magnesium.

3. TMJ disorder

The temporal mandibular joint (TMJ) is the joint where your jaw connects with your skull. The joints are located in front of your ears on either side of your face. If your teeth are misaligned or you grind your teeth, a condition called bruxism, you can develop dysfunction and pain at the TMJ.

Symptoms of TMJ dysfunction include popping of the joint, pain at the joint, difficulty opening your mouth, and headaches. Proper diagnosis and treatment require that you see a dentist familiar with this condition. The headaches caused by TMJ can be misdiagnosed as migraines and TMJ can be a trigger for migraines.

4. Thyroid disease

Both low and high thyroid levels can cause headaches. Thyroid disease, usually associated with fatigue, dry skin, and hair loss when thyroid levels are low, and rapid heart rate and anxiety when thyroid levels are high, may present with migraine as the only significant symptom. This so-called subclinical presentation of thyroid disease can also be seen in adults and children.

Diagnosis can be made with a simple blood test.

5. Mold toxicity

This is highly controversial, but in my experience, mold toxicity is a significant cause of many diseases, including migraines. Molds can produce allergic reactions when inhaled, but the bigger concern is the toxins called mycotoxins that are chemical toxins present within or on the surface of the mold.

Mold toxins can affect almost every organ in the body, but the brain is almost always affected, resulting in neurotoxicity. People with mold toxicity have complaints that vary from mild cognitive impairment to symptoms that look like multiple sclerosis.

Headaches are a common complaint of people suffering from mold toxicity. Mold toxicity should be considered in anyone who has migraines and a history of exposure to water-damaged buildings where mold grows. Unfortunately, very few doctors know about this condition or how to evaluate a patient for the problem. For more information on mold toxicity, see the Biotoxicity and Neurotoxicity page on this website or visit Dr. Shoemaker’s website SurvivingMold.com.

As it turns out, Lindsay’s migraines were a result of being gluten intolerant and having low magnesium levels. Once she eliminated all gluten from her diet and improved her magnesium levels with magnesium IVs, her migraines dramatically improved.

We are here for you, and we want to help.

Our goal is to return you to optimal health as soon as possible. To schedule an appointment please call: 703-532-4892 x2

Young woman losing parts of head as symbol of decreased mind function.

Addressing the Fear of Cognitive Decline & How to Be Proactive

/in , , /by

Alzheimer’s disease, the most common form of dementia, is the sixth leading cause of death in the U.S. For most people, the subject of Alzheimer’s brings fear and trepidation. Why? Because the thought of deteriorating brain function and memory loss is frightening. Unfortunately, current medical treatments are inadequate, dealing only with its end result.

Alzheimer’s is characterized by the destruction of synapses in the neurons, the nerve cells in the brain, by amyloid plaques. In addition, “tangles” form in the cells leading to loss of brain function. This leads to progressive loss of memory and behavioral problems like aggression, hallucinations, and delusions, as well as deterioration of activities of daily living. This is heartbreaking for patients and their families. And, despite years of ongoing research, there are still many unanswered questions about what causes Alzheimer’s disease.

Let’s explore some of the known risks associated with dementia and learn how to lower those risks.

Type 3 Diabetes

You may not have heard the term “type 3 diabetes” as another name for Alzheimer’s Dementia. Type 2 diabetes and prediabetes, also called insulin resistance, are both strongly linked to the development of Alzheimer’s dementia. This could actually be good news because it means this is a preventable risk factor.

Why has the term Type 3 diabetes been coined?  Let’s start by discussing sugar, which in large quantities is a poison. The body is not designed to handle more than 15-20 grams per day, yet a soda has at least 40 grams and the average American consumes 82 grams per day.

Excess sugar causes an outpouring of insulin from the pancreas and over time causes the cells in the body – including the brain – to become resistant to insulin. This leads to chronically elevated blood sugar which causes Advanced Glycation End products or AGEs to be produced. These AGEs then attack the eyes, kidneys, peripheral nerves, and the brain!

Environmental factors

Heavy metals, such as lead in pollution and mercury in dental amalgams, and large fish, like tuna, swordfish, and shark increase the risk of dementia. In the 1800s the term “mad as a hatter” came about because hat makers were using a form of mercury to make fur hats and it destroyed brain cells.

Living or working in a water-damaged building leads to the growth of toxic mold, which poisons the nervous system.

Studies also show that living near major highways is a risk factor for Alzheimer’s.

Other causes of dementia include:

  • Recurrent traumatic brain injury (concussions)
  • Infections like Lyme disease and syphilis
  • Excess alcohol and drugs
  • Prolonged general anesthesia
  • Sleep apnea
  • There are several genes that predispose to Alzheimer’s such as the ApoE4. However, just because we have a gene does not mean it will be expressed. Every time we eat, exercise, sleep, meditate, communicate, create something, play, learn, and love, we are turning genes on and off.

Questions? Give Us a Call!

703-532-4892 x2

The good news is the brain can actually grow and change in a positive way, even as we get older.

Be proactive in reducing your risk of dementia with these strategies:

Lifestyle strategies can promote neurogenesis (new brain cells) and neuroplasticity (changes in the brain and its pathways). These strategies involve a substance called BDNF or brain-derived neurotrophic factor, which promotes brain cell growth and connectivity as demonstrated on MRI scans. In fact, the hippocampus, which is involved in emotional memory, gets larger the more BDNF is available. A large part of the lifestyle strategy involves modifying the diet to lower unhealthful carbs and increase healthful fats thus lowering the risk of diabetes.

  1. Reduce (non-vegetable) carbohydrate consumption.
    Sugars/artificial sweeteners and grains can cause inflammation of the lining of the digestive tract, or “leaky gut”. An inflamed gut causes an inflamed brain and reduces the size of the hippocampus. Functional testing looking at stool, urine, and breath can determine if your gut is leaky. Replace nutrients lost from a leaky gut or poor diets like B12, folate, B6, magnesium, and iron.
  2. Increase healthy fat consumption.
    Increase your omega-3 fat intake and reduce the consumption of damaging omega-6 fats (like processed vegetable oils) in order to balance your omega-3 to omega-6 ratio. Omega-3 from fish sources shows a lower risk of cognitive impairment.
  3. Add prebiotics & probiotics to your diet.
    Prebiotic fiber nurtures gut bacteria and the hippocampus. Probiotic supplementation, which enhances the healthy bacteria in the gut, decreases the inflammatory marker, C-reactive protein, increases the antioxidant  glutathione, and improves mental status as measured by the Mini Mental Status Exam
  4. Improve your sleep habits.
    Work on getting at least 7-8 hours of solid sleep. If sleep is poor, rule out sleep apnea. A 2020 study published in the journal Sleep confirms that people who have obstructive sleep apnea – or intermittent interruptions in breathing – in their middle ages are more likely to develop Alzheimer’s Disease. If you’re not sure if you have sleep apnea, but you find yourself exhausted during the day, take this short quiz as the first step towards diagnosis.
  5. Exercise!
    Physical activity produces biochemical changes, increasing BDNF, that strengthen and renew not only your body but also your brain – particularly the hippocampus, the area associated with memory and learning. This is especially important for carriers of the ApoE4 gene. A good exercise regimen includes aerobic and resistance training at least 3-4 times per week for 30-45 minutes.
  6. Try Niagen+ IV Therapy to boost NAD+ levels.
    Sirtuins, which are NAD+-dependent enzymes, have shown to benefit brain health by acting on amyloid plaques, repairing DNA, lowering inflammation, and promoting neuronal function, which in turn can prevent or delay the onset of mild cognitive decline. Click here to learn how Niagen+ IVs help boost NAD+ levels.
  7. Go Keto.
    The ketogenic diet. is linked to an increase in BNDF, which causes the hippocampus to get bigger (better memory). This involves cutting down on carbohydrates which reduces insulin resistance (diabetes) and increasing good fats like avocado, olive oil, MCT (medium-chain triglycerides found in coconut oil), and intermittent fasting 12-14 hours between dinner and breakfast so that the body breaks down fats and produces ketones. Note: The Ketogenic diet is not for everyone, ask your physician before starting any specialized diet.
  8. Eliminate toxins.
    Consider getting tested for heavy metal and toxic mold exposure and work with your doctor to eliminate them.
  9. Check your hormone levels.
    Balance hormones, such as thyroid, cortisol, sex hormones, and Vitamin D (which is actually a hormone).
  10. Find out whether you are insulin resistant.
    Get a HgA1C test and a fasting insulin test. Eliminating the risk of Type 2 diabetes (insulin resistance) can lower the risk of Alzheimer’s dementia (Type-3 Diabetes).
  11. Remember to take time to slow down, be mindful (meditation and yoga) spend time with loved ones, and take time to laugh and have fun. This is medicine for our minds.

Lisa Lilienfield, MD

BUILDING A BETTER BRAIN
Read more about our comprehensive services for patients who want to maintain brain health or who have been diagnosed with mild cognitive decline. 

MORE INFO